The SportsLine Projection Model simulates every FBS college football game 10,000 times. South Florida picks, be sure to check out the college football predictions and betting advice from SportsLine's proven computer model. UTSA odds via SportsLine consensus, while the over/under for total points scored is 66.5. The Roadrunners are favored by 15.5 points in the latest South Florida vs. USF is averaging 264.6 passing yards per game in 2023, while UTSA averages 238. This will be the first meeting between the schools.

The Roadrunners (7-3, 6-0 AAC), who have won six in a row and 16 consecutive conference games, defeated Rice 34-14 on Saturday. The Bulls (5-5, 3-3 AAC), who have won two of the past three games, are coming off a 27-23 victory over Temple on Saturday.

The South Florida Bulls battle the UTSA Roadrunners in a key American Athletic Conference matchup on Friday night in San Antonio.